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Jump To:. Cadence OrCAD Portable App – Download OrCAD Portable for PC and Mac. (223,455 downloads).Debbe Fishbach has always been a strong supporter of BioMarin Pharmaceutical Inc., which is a leading maker of genetically modified embryos that it markets to women for their safety, cost and convenience. Last year, she stood by in an aisle at a biotech conference and cheerfully accepted a luncheon plate of salmon from one of its top executives.

But after reading an article about the company in The New York Times on Friday, Ms. Fishbach said she was horrified by the company’s plan to make a batch of embryonic stem cells from her own and her fellow oocyte donor’s embryos.

Ms. Fishbach, a 47-year-old attorney, is now a critic of BioMarin’s plan to destroy the embryos’ genes before it makes them into the replacement cells that could treat her mother, who has Parkinson’s disease. The American Society for Reproductive Medicine, which helped Ms. Fishbach as well as the other donor and her partner select a genealogy and gene expression test to screen prospective oocyte donors, is investigating BioMarin’s plans.

For many advocates of embryo research, including Ms. Fishbach and her partner, the prospect of genetically modifying the cells of her ova first seemed perfectly acceptable. Embryos they created and donated years ago, because they were poor donors, had been discarded and needed a new life.

“We have a lot of regrets for the donor,” Ms. Fishbach said, adding that the thought of taking part in her own embryonic death made her feel “sick.” She said she could imagine showing the company her letter to her doctor, asking him not to include her cells in any future stem cell research.

BioMarin officials say the company has an impeccable track record of conduct. If they can gather and edit the correct genes, and genetically modify the cells to create the correct proteins, they say, the resulting cells can be used to treat a variety of diseases and injuries, including osteoarthritis, and for research purposes.

“BioMarin takes its responsibilities very seriously and will adhere to all federal guidelines and regulations related to the production of stem cells,” Tonda Lawson, a spokeswoman for the company, said in a statement.

The company has not created human embryos since 2003, and it has no intention of using other donors’ cells, which are both more plentiful
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